Latest publications:
| DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells Dayana B Hristova, Marisa Oliveira, Emma Wagner, Alan Melcher, Kevin J Harrington, Alexandre Belot, Brian J Ferguson iScience, in press | 2023 |
| Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing Rahul Singh, Yuan Wu, Alba Herrero del Valle, Kendra E Leigh, Mark TK Cheng, Brian J Ferguson, Yorgo Modis bioRxiv, 2023.05. 25.542247 | 2023 |
| Mechanisms of type I interferon production by chicken TLR21 Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T Manna, Mélanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E Bryant, Brian J Ferguson Developmental & Comparative Immunology 151, 105093 | 2023 |
| LUBAC is required for RIG-I sensing of RNA viruses Helena C Teague, Charlotte Lefevre, Eva Rieser, Diego de Miguel, Daniel Patricio, Marisa Oliveira, Daniel S Mansur, Nerea Irigoyen, Henning Walczak, Brian J Ferguson Cell Death & Differentiation, 1-12 | 2023 |
| Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV Delphine M Depierreux, Geoffrey L Smith, Brian J Ferguson Frontiers in Immunology 14, e1093381 | 2023 |
| The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken Rodrigo Guabiraba, Vincent Saint-Martin, Vanaique Guillory, Melanie Chollot, Isabelle Fleurot, Emmanuel Kut, Ferdinand Roesch, Ignacio Caballero, Emmanuelle Helloin, Emilie Chambellon, Brian Ferguson, Philippe Velge, Florent Kempf, Sascha Trapp ResearchSquare Pre-print | 2023 |
| PKR-mediated stress response enhances dengue and Zika virus replication Taissa Ricciardi-Jorge, Edroaldo Lummertz da Rocha, Edgar Gonzalez-Kozlova, Gabriela Flavia Rodrigues-Luiz, Brian J Ferguson, Trevor Sweeney, Nerea Irigoyen, Daniel Santos Mansur Mbio 14 (5), e00934-23 | 2023 |
| Suppression of innate immunity by the vaccinia virus protein N1 promotes skin microbiota expansion and increased immune infiltration following vaccination Evgeniya Shmeleva, Daneil Syafiq, Anna Moldoveanu, Brian J Ferguson, Geoffrey L Smith Journal of General Virology 103 (11) | 2022 |
| DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response Daniel de Oliveira Patricio, Greicy Brisa Malaquias Dias, Lucilene Wildner Granella, Ben Trigg, Helena Claire Teague, Dina Bittencourt, André Báfica, Alfeu Zanotto-Filho, Brian Ferguson, Daniel Santos Mansur Frontiers in Immunology 13, 1042463 | 2022 |
| Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and enhance immunity Evgeniya V Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J Enright, Andrew J Macpherson, Brian J Ferguson, Geoffrey L Smith PLoS pathogens 18 (4), e1009854 | 2022 |
| Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies Delphine M Depierreux, Arwen F Altenburg, Lior Soday, Alice Fletcher-Etherington, Robin Antrobus, Brian J Ferguson, Michael P Weekes, Geoffrey L Smith PLoS Pathogens 18 (6), e1010612 | 2022 |
| Chicken cGAS senses fowlpox virus infection and regulates macrophage effector functions Marisa Oliveira, Damaris Ribeiro Rodrigues, Vanaique Guillory, Emmanuel Kut, Efstathios S Giotis, Michael A Skinner, Rodrigo Guabiraba, Clare E Bryant, Brian J Ferguson Frontiers in Immunology 11, 3716 | 2021 |
| Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node Juliana Bernardi Aggio, Veronika Krmeská, Brian J Ferguson, Pryscilla Fanini Wowk, Antonio Gigliotti Rothfuchs The Journal of Immunology 206 (4), 776-784 | 2021 |
| Exploiting Connections for Viral Replication Louise H Wong, James R Edgar, Andrea Martello, Brian J Ferguson, Emily R Eden Frontiers in Cell and Developmental Biology 9, 284 | 2021 |
| Viral interactions with non-homologous end-joining: a game of hide-and-seek Dayana B Hristova, Katharina B Lauer, Brian J Ferguson The Journal of General Virology 101 (11), 1133 | 2020 |
| ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis Paula Fernandes dos Santos, Johan Van Weyenbergh, Murilo Delgobo, Daniel de Oliveira Patricio, Brian J. Ferguson, Rodrigo Guabiraba, Tim Dierckx, Soraya Maria Menezes, André Báfica and Daniel Santos Mansur Journal of Immunology, Volume 200(2) | 2018 |
| The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection Ben J. Trigg, Katharina B. Lauer, Paula Fernandes dos Santos, Heather Coleman, Gabriel Balmus, Daniel S. Mansur and Brian J. Ferguson Viruses, Volume 9(11) | 2017 |
| Genome-wide analyses reveal a highly conserved Dengue virus envelope peptide which is critical for virus viability and antigenic in humans RC Fleith, FP Lobo, PF dos Santos, MM Rocha, J Bordignon, DM Strottmann, DO Patricio, WR Pavanelli, M Lo Sarzi, CN Dos Santos, BJ Ferguson, DS Mansur Scientific Reports 6, Article number: 36339 | 2016 |
| LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation J Zinngrebe, E Rieser, L Taraborrelli, N Peltzer, T Hartwig, H Ren, I Kovács, C Endres, P Draber, M Darding, S von Karstedt, J Lemke, B Dome, M Bergmann , BJ Ferguson*, H Walczak* J Experimental Medicine (In Press) | 2016 |
| Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators RP Sumner, H Ren, BJ Ferguson, GL Smith Vaccine Volume 34, Pages 4827–4834 | 2016 |
| The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1beta secretion in macrophages BJ Ferguson, S Newland, SE Gibbs, P Tourlomousis, P Fernandes dos Santos, MN Patel, SW Hall, H Walczak, G Schramm, H Haas, DW Dunne, A Cooke, and P Zaccone International Journal for Parasitology Volume 45, Issue 13 Pages 809–813 | 2015 |
| Functions of DNA damage machinery in the innate immune response to DNA virus infection BJ Trigg and BJ Ferguson Current Opinion in Virology Volume 15, Pages 56–62 | 2015 |
| International Union of Basic and Clinical Pharmacology. XCVI. Pattern Recognition Receptors in Health and Disease CE Bryant, S Orr, BJ Ferguson, MF Symmons, JP Boyle, and TP Monie Pharmacological Reviews vol. 67 no. 2 462-504 | 2015 |
| Enhancement of CD8+ T‐cell memory by removal of a vaccinia virus NF‐κB inhibitor H Ren, BJ Ferguson, C Maluquer de Motes, RP Sumner, L Harman, GL Smith Immunology 145 (1), 34-49 | 2015 |
| The role of shed placental DNA in the systemic inflammatory syndrome of pre-eclampsia JDR Hartley, BJ Ferguson, A Moffett American Journal of Obstetrics and Gynecology Volume 213, Issue 3, Pages 268–277 | 2015 |
| Intracellular sensing of viral DNA by the innate immune system DS Mansur, GL Smith, BJ Ferguson Microbes and Infection 16 (12), 1002-1012 | 2014 |
| Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo CH Ku, BJ Ferguson J Vis Expts e51593-e51593 | 2014 |
| A mechanism for the inhibition of DNA-PK mediated DNA sensing by a virus NE Peters, BJ Ferguson, M Mazzon, AS Fahy, E Krystofinska, R Arribas-Bosacoma, LH Pearl, H Ren, GL Smith PloS Pathogens 9(10): e1003649 | 2013 |
| Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity GL Smith, CTO Benfield, CM de Motes, M Mazzon, SWJ Ember, BJ Ferguson, RP Sumner Journal of General Virology, 94: 2367-2392 | 2013 |
| A mechanism for induction of a hypoxic response by vaccinia virus M Mazzon, NE Peters, C Loenarz, EM Krysztofinska, SWJ Ember, BJ Ferguson, GL Smith Proceedings of the National Academy of Sciences, 110 (30), 12444-12449 | 2013 |
| Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence BJ Ferguson, CTO Benfield, H Ren, VH Lee, GL Frazer, P Strnadova, RP Sumner, GL Smith Journal of General Virology, 94 (9), 2070-2081 | 2013 |
| Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence DS Mansur, CM de Motes, L Unterholzner, RP Sumner, BJ Ferguson, H Ren, P Strnadova, AG Bowie, GL Smith PLoS pathogens 9 (2), e1003183 | 2013 |
| Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence SWJ Ember, H Ren, BJ Ferguson, GL Smith Journal of General Virology 93 (Pt 10), 2098-2108 | 2012 |
| DNA-PK is a DNA sensor for IRF-3-dependent innate immunity BJ Ferguson, DS Mansur, NE Peters, H Ren, GL Smith eLife Sciences 1 e00047 | 2012 |
| Mapping the IκB kinase β (IKKβ)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKβ-mediated activation of NF-κB CTO Benfield, DS Mansur, LE McCoy, BJ Ferguson, MW Bahar, AP Oldring, JM Grimes, DI Stuart, SC Graham, GL Smith Journal of Biological Chemistry 286 (23), 20727-20735 | 2011 |
| Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export GW Morgan, M Hollinshead, BJ Ferguson, BJ Murphy, DCJ Carpentier, GL Smith PLoS pathogens 6 (2), e1000785 | 2010 |
| PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool W Li, BJ Ferguson, WT Khaled, M Tevendale, J Stingl, V Poli, T Rich, P Salomoni, CJ Watson Proceedings of the National Academy of Sciences 106 (12), 4725-4730 | 2009 |
| Death in the AIRE BJ Ferguson, A Cooke, P Peterson, T Rich Trends in immunology 29 (7), 306-312 | 2008 |
| New insights into the role of PML in tumour suppression P Salomoni, BJ Ferguson, AH Wyllie, T Rich Cell research 18 (6), 622-640 | 2008 |